ULTRASTRUCTURAL CHANGES OF THYROTROPIC CELLS IN THE DYNAMICS OF EXPERIMENTAL IMMUNOSTIMULATION
Abstract
The endocrine and immune systems are interrelated via a bidirectional network.Thyroid-stimulating hormone plays a critical role as an endogenous mediator of immune activity. Purpose of study was to determine the dynamics of changes of thyrotropic cells ultrastructure in modeling immunostimulation in mature male rats by subcutaneous injection of imunofan in a dosage 0,7 mg/kg of body weight.The pituitary samples were taken on 1st, 7th, 15th, 30th and 60th, day after treatment and thenfixed in glutaraldehyde for electron microscope. The study showed theincrease of functional activity of the thyrotropic cells. The significant increase of areas of the cells and their nuclei, area of mitochondria and secretory granules was established since 7th day after imunofan treatment.
References
Armstrong, M. D. & Klein, J. R. (2001). Immune-Endocrine Interactions of the Hypothalamus-Pituitary-Thyroid Axis: Integration, Communication and Homeostasis. Archivum Immunologiae et Therapiae Experimentalis, 49, 231–237.
Coutelier, J., Kehrl, J. H., Bellur, S. S., Kohn, I. D., Notkin, A. L. & Prabhakar, B. S. (1990). Binding and functional effects of thyroid stimulating hormone on human immune cells. Journal of Clinical Immunology, 10, 204–210. http://dx.doi.org/10.1007/BF00918653 PMid:2170438
Gaillard, R. C. (2001). Interaction between the hypothalamo-pituitary-adrenal axis and the immunological system. Ann Endocrinol (Paris), 62 (2), 155-163.
Gaillard, R. C. (2003). Interactions between the immune and neuroendocrine systems: clinical implications. J Soc Biol, 197 (2), 89-95.
Granado, M., Garc-a-Ceres, C. & Tuda, M. (2011). Insulin and growth-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats. Molecular and Cellular Endocrinology, 337 (1-2), 101-103. http://dx.doi.org/10.1016/j.mce.2011.02.002 PMid:21352888
Harbour, D. V., Leon, S., Keating, C. & Hughes, T. K. (1990). Thyrotropin modulates B cell function through specific bioactive receptors. Prog. Neuroendocrinimmunol, 3, 266–276.
Jara, L. J., Navarro, C. & Medina, G. (2006). Immune-neuroendocrine interactions and autoimmune diseases. Clin. Dev. Immunol, 13(2-4), 109-123. http://dx.doi.org/10.1080/17402520600877059 PMid:17162354 PMCid:2270761
Karl, T. & Weber, A. (2003). Neuroendocrine-Immune Interface. Journal Herz, 28 (8), 692-701. http://dx.doi.org/10.1007/s00059-003-2511-y PMid:14689103
Kruger, T. E., Smith, I. R., Harbour, D. V. & Blalock, J. E. (1989). Thryrotropin: an endogenous regulator of the in vitro immune response. J. Immunol, 142, 744–747. PMid:2492328
Lebedev, V. V. & Pokrovsky, V. I. (1999). Imunofan – sinteticheskiy peptidniy preparat novogo pokoleniya [Imunofan - synthetic peptid preparation of new generation]. Vestnik of RAMN, 4, 56-61.
Markovich, L. (2004). Interaction involving the thymus and the hypothalamus-pituitary axis, immunomodulation by hormones. Srpski arhiv za celokupno lekarstvo, 132 (5-6), 187-193. http://dx.doi.org/10.2298/SARH0406187M
Ribakina, E. G. & Korneva, E. A. (2005). Transduktsiya signala interleukin-1 v protsessakh vzaimodeystviya nervnoy i imunnoy system organizma [Transduction of signal of interleukin-1 in the processes of co-operation of the nervous and immune systems of organism. Vestnik of RAMN, 7, 3-8.
Sepiashvilli, R. I. (2003). Funktsionalnaya sistema immunnogo gomeostaza [Functional system of immune homeostasis]. Allergologia i immunologia, 2, 5-14.
Tirtishnaya, G. V. & Parahonsky, A. P. (2007). Vzaimosvyaz narusheniy immunnoy i endocrinnoy system pri autoimmunnoy patologii [Intercommunication of disoders of the immune and endocrine systems at autoimmune pathology]. Modern science intensive technologies, 2, 80-81.
Weigent, D. A., Carr, D. J. & Blalock, J. E. (1990). Bidirectional communication between the neuroendocrine and immune systems. Common hormones and hormone receptors. Ann. N. Y. Acad. Science, 579, 17-27. http://dx.doi.org/10.1111/j.1749-6632.1990.tb48350.x PMid:2186684
Weigent, D. A. & Blalock, J. E. (1995). Associations between the neuroendocrine and immune systems. J. Leukoc. Biol., 8, 137-150.
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