NITROGEN MONOXIDE AS A FACTOR OF ACTIVATION OF THE PROOXIDANT SYSTEM ON THE BACKGROUND OF SUBSIDIES OF HIGH CONCENTRATIONS OF OXYGEN IN NEWBORNS WITH RESPIRATORY DISTRESS

Abstract

Data about the peculiarities of metabolism of endogenous NO in modern literature are quite controversial, especially in newborns with respiratory distress who need artificial lung ventilation. Investigating of the peculiarities of peroxidation processes on the background of excessive accumulation of nitrogen monoxide metabolites due to the inhalation of different concentrations of oxygen among newborns with severe respiratory insufficiency.

84 newborns who were admitted to the department of intensive care of newborns were under investigation. They were randomized into groups according to their oxygen saturation index of the inhaled mixture. The exhaled breath condensate was tested for nitrogen monoxide metabolites, malonic aldehyde, aldehyde and ketone derivatives of the 2,4-dinitrophenyl hydrazine of a neutral and basic (aggregates of protein molecules) nature.

Obtained results indicated that nitrogen monoxide (active oxidant) directly affects the increase of activity of processes of proteins and lipids peroxidation by increasing the total oxidation potential. Excessive endogenous NO formation under the conditions of subsidizing of high concentrations of oxygen leads to an increase in excessive formation of nitrogen monoxide and is a risk factor for the initiation of oxidative stress processes.

Thus, nitrogen monoxide is one of the factors of activation of free radical oxidation at the level of alveolar-capillary space among newborns with respiratory distress. In intensive care for newborns with severe respiratory failure, the use of excessive oxygen concentrations should be avoided, as on the background of increased endogenous NO formation, there is a risk factor for the toxic effect of oxygen on the biological structures due to the increased formation of active forms of oxygen with the development of oxidative stress.