THE POSSIBILITIES OF MR TRACTOGRAPHY IN DIAGNOSTICS OF SYMPTOMATIC EPILEPSY IN CHILDREN WITH DIFFERENT GENESIS

Khabibulla Aminov

Abstract


In this article the possibilities of MR tractography in symptomatic epilepsy patients have been presented. We determined the quantitative standards of numerical values of diffusion of white matter in children with symptomatic epilepsy of various etiology. In children with symptomatic epilepsy, the pathological changes of white matter were localized not only in the epileptogenic, but also in the opposite hemisphere. The regions with abnormal white matter FA and ADC values not only matched to limbic circle zones, but also to areas of intra- and interhemispheric connections uniting the frontal, temporal, parietal and occipital lobes of the brain. Determining the specific clusters of brain tracts in symptomatic epilepsy, regardless of etiology, is important to predict the prognosis of the disease and the likely possibility of cognitive impairment. The study proved that symptomatic epilepsy is characterized by a variety of changes in the white matter of the brain tracts that lead to the dissociation of certain regions of the brain, interrupting connections between cortical and subcortical regions and inhibiting the transfer of information. It can be concluded, that diffusion-weighted imaging are much more sensitive to the structural and metabolic changes occurring in the brain, in comparison with conventional MRI images.


Keywords


Symptomatic epilepsy, MR tractography, Fractional anisotropy, Average diffusion capacity.

Full Text:

PDF

References


Basser P.J, Mattiello J, & Le Bihan D (1994). MR diffusion tensor spectroscopy and imaging. Biophysical Journal 66 (1): 259–267. Bibcode:1994BpJ....66..259B.doi:10.1016/S0006-3495(94)80775-1. PMC 1275686. PMID 8130344.

Bazilevich, C.N., Odinak, M.M., Diskin, D.E., & Krasakov, I. V. (2008). The results of structural and functional neuroimaging in patients with epileptic seizures in cerebrovascular diseases. Journal of neurology named after S.Korsakov (Epilepsy. Appendixof the journal). 2: 33-39.

Gromov, S.A. (2003). Epilepsy: proceedings of the conference "Actual problems of modern neurology, psychiatry and neurosurgery." 21-26.

Hagmann, B., Jonasson, L., Maeder, P., Thiran, J., Pandya, D., & Meuli, R. Understanding Diffusion MR Imaging Techniques: From Scalar Diffusion-weighted Imaging to Diffusion Tensor Imaging and Beyond. RadioGraphics. Oct 2006. Retrieved from http://radiographics.rsna.org/content/26/suppl_1/S205.full.

Kisten, O.V. (2012) Experience of diffusion tensor magnetic resonance imaging in the morphological diagnosis of epilepsy. Neurology and Neurosurgery. 4: 95-97.

Le Bihan D, (2012) . MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology, 161: 401- 407.

Le Bihan, D. (2006). Direct and fast detection of neuronal activation in the human brain with diffusion MRI. Proceedings of the National Academy of Sciences 103 (21): 8263–8268. Bibcode:2006PNAS..103.8263L. doi:10.1073/pnas.0600644103.

Posse, S., Cuenod, C.A., & Le Bihan, D. (1993). Human brain: proton diffusion MR spectroscopy. Radiology 188 (3): 719–25. PMID 8351339.

Richards, T.L., Heide, A.C., Tsuruda, J.S., & Alvord, E.C. (1992). Vector analysis of diffusion images in experimental allergic encephalomyelitis. Presented at Society for Magnetic Resonance in Medicine, Berlin, SMRM Proceedings 11:412, (abstr).

Thomsen, C., Henriksen, O., & Ring, P. (1997). In vivo measurement of water self diffusion in the human brain by magnetic resonance imaging. Acta Radiologica, 28:353–361.

Wedeen, V.J. Wang, R.P. Schmahmann, J.D., Benner, T., Tseng, W.Y, Dai, G., Pandya, D.N., Hagmann, P., & D'arceuil, H. (2008). Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers. NeuroImage 41 (4): 1267–77.doi:10.1016/j.neuroimage.2008.03.036. PMID 18495497.




DOI: http://dx.doi.org/10.12955/emhpj.v8i2.702

Refbacks

  • There are currently no refbacks.


Print ISSN 1804-5804, Online ISSN 1804-9702

(c) 2018 CBU,o.p.s.