CHARACTERIZATION OF VEGETATIVE CHANGES IN BRONCHIAL ASTHMA OF VARIOUS SEVERITIES IN CHILDREN

Hurmatoy Khankeldieva, Ibrohim Alimjanov, Habiba Negmatshaeva, Mavjuda Abdullaeva, Temur Tojiboev, Marifat Ganieva

Abstract


This article presents a study of the state of vegetative balance and prognostic possibilities of quantitative parameters of functional activity of VNS to estimate a state of bodily adaptive reserves in children with severe BA. Bronchial asthma, being one of the most common chronic diseases in childhood, requires further research into predisposing and causally-significant factors, mechanisms of pathogenesis and peculiarities of a clinical course, improvement of methods of diagnostics, treatment, and prevention. Great importance in the development of bronchial asthma in children is given to genetically-fixed functional insufficiency of barrier tissues of the respiratory system, increased ability to synthesize allergic antibodies and produce certain cytokines, high bronchopulmonary sensitivity to mediators of allergic inflammation, lowered sensitivity of 3g-adrenoreceptors to endogenous catecholamins, changes in immunologic responsiveness, and disorder of neuroendocrinal regulation of immune responses. Implementation of genetic predisposition to bronchial asthma development is promoted by influence of adverse environmental factors.


Keywords


bronchial asthma, catecholamins, neuroendocrinal regulation, bronchopulmonary sensitivity

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References


Baevski, R. M., Ivanov, G. G, & Chireikin, L.V. (2001). Analysis of variability of cardiac rhythm in utilisation of various electrocardiographic systems: Method, recommendations. Vestnik aritmologii. 24, 66-85.

Balabolkin, I. I, Lukina, O. F, Goncharova, N. V., & Yukhtina, N. (2001). Clinical functional criteria of bronchial asthma severity in children and efficacy of basic therapy. Pediatra. 5, 4-9.

Bolova, A. A., Uvarova, E. V., & Yakushenko, M. N. (2008). Estimation of adaptive potential of the body and initial tonus of autonomous nervous system in girls aged 8-17 years. Pediatricheskaya farmakologia, 5(6), 22–25.

Galustyan, A. N., Korostovtsev, D. S, & Makarova, I. V. (1998). Prognosis of prevention of allergic diseases in children, 2, 81-83.

Guryanova, Ye. M., Igisheva, L. N., & Galeyev, A. R. (2003). Peculiarities of cardiac rhythm variability in children with bronchial asthma. Pediatria, 4, 32–36.

Klyucheva, M. G., Ryvkin, A. I., & Troitskaya, I. N. (2005). Analysis cardiac rhythm variability in estimation of vegetotropic effects of bronchodilators in bronchial asthma of adolescents. Klinicheskaya farmakologia i therapia, 5, 85–87.

Mizernitski, Yu. L. (2003) Aetiology, pathogenesis and clinical variants of bronchial asthma in children. Pulmonologia detskogo vozrasta: problemi i reshenia. Moscow, 3, 144–151.

Vein, A. M. (Ed.). (2005). Diseases of vegetative nervous systems. Handbook for doctors, 8, 74-77. Moscow.




DOI: http://dx.doi.org/10.12955/emhpj.v8i1.671

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