The Study Drug Pathomorphism And Immunohistochemical Parameters Of Tumor In Endoarterial Of Regional Long-Term Chemotherapy In Treatment Of Cervical Cancer
Background: To improve the results of radiotherapy for cervical cancer used local and systemic radio-modification drugs.
Materials and methods: 1984 patients with locally advanced cervical cancer (2b - 3a stage), which at one stage of complex treatment by a course indo-arterial of regional long-term poly-chemotherapy (EARDPHT) mode: methotrexate - 50 mg/m2, the first 12 hours, fluorouracil 1000 mg/m2, over the next 12 hours and cisplatin - 100 mg/m2, for 48 hours, 2 stage - surgical treatment in the volume expanding hysterectomy 3 type (modification of Wertheim - Meigs).
Results: The results of treatment of locally cervical cancer using VADRPHT, depending on the unilateral and bilateral tumor invasion in parametrial tissue showed that under unilateral lesion of parametrium results of treatment were higher than for the bilateral involvement of parametrium. Medical pathomorphosis in tumors of different severity was observed in 86.9% of patients, metastasis to regional lymph nodes were detected in 36% of operated patients, and also studied the degree of therapeutic pathomorphosis in lymph nodes. There was revealed that the complete regression of tumors, 5 - year survival rate is 98%, whereas in tumor regression of more than 50% of the original volume – 78.5%, with stabilization of tumor - no more than 58.4%.
Conclusion: The study of molecular-biological parameters of the tumor cells show the effectiveness of conducted neo-advent indo-arterial chemotherapy and play an important role in further treatment and prediction of disease.
Peters W.A., Liu P.Y.,Barret R.J. et al. Concurrent chemotherapy and pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of cervix J.Clin. Oncol. 2000. Vol. 18, № 8. P. 1606-1613.
Rotman M., Sedlis A., Piedmonte M.R. et al. a phase 111 randomized trial of pelvic pelvic field in post-operative irradiation in Stage 1B cervical carcinoma with poor prognostic features: Follow-up of a Gynecologic Oncology Group Study Int. J. Rad. Oncol. Biol. Phys. 2006. Vol. 65. P. 169-176.
Ohara K., Tsunoda M. et al. Use of small pelvic field instead of whole pelvic field in post operative radiotherapy for nodenegative, high-risk stages 1 and 11 cervical squamous cell carcinoma Int. J. Gynecol. Cancer. 2003. Vol. 13. P. 170-176.
Benedet J.L. Carcinoma of the cervix uteri. J. Gynecol. Obstet. 2003; V. 83: 1: 41-78/
Obrzut B., Skret A., Marzanna O. et al. Discrepancies between clinical and surgical-pathological staging of cervical carcinoma. Gynekol. Pol. 2006; V. 77(7): 510-515.
Odicino F. New development of the FIGO staging system/ Gynecol. Oncol. 2007; V. 107(1): 1: 8-9/
Ohno T., Nakano T., Kato S. et al. Accelerated hyperfactionated radiotherapy for cervical cancer: Multi-inatitutional prospective study of forum for nuclear cooperation in Asia among eight Asian countries. J. radiat. Oncol. Biol. Phys. 2007; V. 3. 1522-1529.
Yeung A.R., Amdur R.J., Morris C.G. et. al. Long-term outcome after radiotherapy for FIGO stage 111B and 1V A carcinoma of the cervix. J. radiat. Oncol. Biol. Phys. 2007; V. 67.(5):1445-50.
Benedet J.L., Odicino F., Maisonneuve P., et al. Carcinoma of the cervix uteri.J. Gynecol. Obstet 2003; V.83: 1:41-78.
Dargent D., Lamblin G., Romestaing P. et al. effect of radiotherapy on pelvic lymph node metastasis in cervical cancer stages IB2-IVA: a retrospective analysis of two comparative series. J.Gynecol Cancer.2005: V. 15(3): 468-474.
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