STUDY OF MACRO- AND MICROELEMENTS COMPOSITION IN THE BIOLOGICAL MEDIA, CLINICAL AND NEUROLOGICAL CHANGES IN PATIENTS WITH CONSEQUENCES OF TRAUMATIC BRAIN INJURY

  • Mansur Aliev Neurosurgery Department of Samarkand State Medical Institute
  • Abdurakhmon Mamadaliev Neurosurgery Department of Samarkand State Medical Institute
Keywords: macroelements, microelements, GOSE, consequences, TBI, cerebrospinal

Abstract

The aim of this research was to investigate the macro- and microelements composition in the cerebrospinal fluid and in the blood serum of patients, with different consequences of TBI before and after complex treatment, with the use of endolumbal and intracystal introduction of ozone and pyracetam in dynamics.

Macro- and microelements composition was investigated in the cerebrospinal fluid and serum of 83 patients. State of neurological disorders in patients evaluated by the Glasgow Outcome Scale was extended. Thus, positive changes may be noted in the metabolism of macro- and microelements in the blood serum and cerebrospinal fluid of patients who were treated according to our suggested methods – endolumbal introductions of nootropic ozone mixture and endocystal introductions of ozone. 

References

Agzamov, М. K. (1994). Comprehensive assessment of the efficacy of nootropic-ozone therapy in severe traumatic brain injury (The dissertation of candidate of medical sciences), Samarkand State Medical Institute, Uzbekistan.

Akshulakov, S. K. (1995). Clinico-epidemiological study of acute traumatic brain injury and its consequences in the Republic of Kazakhstan (The dissertation of doctor of medical sciences), Burdenko Neurosurgery Institute, Russian Federation.

Aliev, M. A., & Mamadaliev, A. M. (2013). Macronutrient composition of biological media in patients with post-traumatic cerebral arachnoiditis. In Dolgov V.V., Shevchenko O.P. (Eds.)., Proceedings of VIII All-Russian Scientific-Practical Conference "Analytical reliability and diagnostic value of laboratory medicine," Journal of Laboratory, №1/2013 (pp. 23.). Moscow, Russian Federation.

Aliev, M. A., & Mamadaliev, A. M. (2013). Study of Efficacy of Endocystal Ozonetherapy in the Operative Treatment of Posttraumatic Arachnoidal Cysts. In Hee-Won Jung, Black P. (Eds)., Proceedings of XV WFNS Congress, (FA0754)., Seoul, Korea.

Bakiev, S. S. (2002). The use of ozone in the treatment of patients with fractures of the maxillofacial bones (The dissertation of candidate of medical sciences), Samarkand State Medical Institute, Uzbekistan, in Russian.

Bolg’ayev, A. B., & Madiyarov, S. D. (1977). Treatment of chronic arachnoiditis via introduction of ozone in the subarachnoid space. Journal of Neurology and Psychiatry, 2, 227-231.

Boldyrev, A. A., Eshchenko, N. D., Ilyukha, V. A., & Kaivarainen, E. I. (2010). Neurochemistry. Proc. manual for schools. Moscow.

Bradbury, M. B. (1999). Transport of Iron in the Blood-Brain-Cerebrospinal Fluid System. Journal of Neurochemistry, 69(2).

Connor, J. R., & Benkovic S. A. (1992). Iron regulation in the brain: histochemical, biochemical, and molecular considerations. Annals of Neurology, 32, S51-61.

Druzhinin, P. V., Novikov L. F., & Lysikov, Y. A. (2010). Basics of Nutrition. Clinical management, Moscow.

Dubrovina, Y. A. (2007). Endolyumbal introduction of ozone-oxygen mixture in the treatment of traumatic brain injury and its complications: Clinical and neurophysiological evaluation (The dissertation of candidate of medical sciences), Kazan, Russian Federation.

Konovalov, A. N., Likhterman, L. B., & Potapov, A. A. (1998, 2002). Clinical guidelines for traumatic brain injury, 1 & 3. Moscow, “Antidor.”

Konovalov, A. N., Potapov, A. A., Likhterman, L. B., Kornienko, V. N., Kravchuk, A. D., Okhlopkov, V. A., Zakharova, N. Y., & Yakovlev, S. B. (2012). Reconstructive and minimally invasive surgery of outcomes of craniocerebral injury. Moscow.

Levin, H. S., Boake, C., Song, J., McCauley, S., Contant, C., Diaz-Marchan, P., Brundage, S., Goodman, H., & Kotrla, K. J. (2001). Validity and sensitivity to change of the extended Glasgow Outcome Scale in mild to moderate traumatic brain injury. Journal of Neurotrauma, 18, 575-584.

Mazurina, Y. M. (2005). Violation of calcium metabolism in children during the first three years of life with neurological disorders (The dissertation of candidate of medical sciences), Moscow, Russian Federation.

Mamadaliev, A. M. (1988). Predicting outcomes of traumatic brain injury in the acute period (The dissertation of doctor of medical sciences), Burdenko Neurosurgery Institute, Russian Federation.

Mamadaliev, A. M., & Agzamov, M. K. (1993). A method for treating severe traumatic brain injury in the acute period (The patent for the invention of the Russian Federation № 5042297/14/023170 on 07/21/93).

Mamadaliev, A. M., & Aliev, M. A. (2009). The Importance of the Duration Disorders of Consciousness to Prognosis of the Outcome of Cranio-Cerebral Trauma. In Black P. (Eds)., Proceedings of XIV WFNS Congress, Boston, USA.

Mamadaliev, A. M., Shodiev, A. S., Aliev, M. A., & Nabiev, A. A. (2011). By studying the composition of macronutrients are in biological media in post-traumatic cerebral arachnoiditis. In Bersnev V.P. (Eds.)., Abstracts of 10th Russian Scientific-Practical Conference of "Polenov reading’s", St. Petersburg, Russian Federation.

Shakirova, E. G. (2006). Changes of plasma micronutrients in Parkinson's disease and Parkinson's syndrome (The dissertation of candidate of medical sciences), Moscow, Russian Federation.

Stepanchenko, O. A. (2005). Peculiarities of stroke when changing glucose in the blood and cerebrospinal fluid (The dissertation of candidate of medical sciences), Moscow, Russian Federation.

Teasdale, G. M., Pettigrew, L. E., Wilson, J. T., Murray, G., & Jennett, B. (1998). Analyzing outcome of treatment of severe head injury: A review and update on advancing the use of the Glasgow Outcome Scale. Journal of Neurotrauma, 15, 587-597.

Ullubiev, M. A. (2008). Changes of plasma micronutrients in ischemic hemispheric stroke (The dissertation of candidate of medical sciences), Moscow, Russian Federation.

Wilson, J. T., Pettigrew, L. E., & Teasdale, G. M. (1998). Structured interviews for the Glasgow Outcome Scale and the Extended Glasgow Outcome Scale: Guidelines for their use. Journal of Neurotrauma, 15, 573-585.

Wilson, J. T., Pettigrew, L. E., & Teasdale, G. M. (2001). Emotional and cognitive consequences of head injury in relation to the Glasgow Outcome Scale. Journal of Neurology, Neurosurgery, and Psychiatry, 70, 267-268.

Published
2015-04-17
Section
Articles