NEW ASPECTS OF THE PATHOGENESIS OF EPILEPSY
Abstract
We studied 52 patients with epilepsy with the average age of 36.2±14.7 years old. Of them, 38 patients had idiopathic epilepsy, 14 patients had symptomatic epilepsy. Our study has shown that epilepsy is accompanied with increased levels of autoantibodies to NF-200, GFAP, S100, MBP, DNA, GABA and dopamine receptors, testifying to the important role of autoimmune disturbances in the pathogenesis of epilepsy. More severe attacks are accompanied by worsening of neuroimmune dysregulation. The degree and duration of autoimmune process can serve additional diagnostic and prognostic criteria for epilepsies.References
Aarli, J.A. (2000). Epilepsy and the immune system. Arch Neurol, 57 (12), 1689-1692.
Aarli, J.A. (1993). Immunological aspects of epilepsy. Brain Dev, 15 (1), 41-49.
Arroyo, S. (1996). Diagnostico y tratamiento del paciente con epilepsia farmacorresistente. Neurologia, 11 (2), 56-68.
Choi, D.W. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, 1 (8), 623-634.
Engel, J. (1994). Epileptic seizures and syndromes. Ed. P. Wolf. London, 359-368.
Gusev, E.I., Guekht, A.B., Poletaev, A.В., Lusnikova, I.V., Feygina, A.A., Kovaleva, I.U. (2006). Сhanges of serum levels of natural neurotropic autoantibodies in patients with partial symptomatic/cryptogenic epilepsy. Epilepsia, 47(suppl. 3), 38.
Lusnikova, I.V. (2008). Clinical and neuro-immunological aspects of pharmacoresistant epilepsy. Synopsis of PhD thesis, Moscow, In Russian.
Mukhin, K.Y., Petrukhin, A.S. (2000). Idiopathic forms of epilepsy, Moscow, in Russian.
Nikanorova, M.Y. (1997). Symptomatic partial epilepsies. Diagnosis and treatment of epilepsy in children. Ed. Temin P.A., Nikanorova M.Y., 225-234, in Russian.
Odinak, M.M., Dyskin, D.Y. (1997). Epilepsy. Moscow, in Russian.
Poletaev, A.B. (1995). Regulatory autoantibodies. Monoclonal antibodies in neurobiology, Novosibirsk, 37-47, in Russian.
Poletaev, A.B., Abrosimova, A.A., , Sokolov, M.A., Guekht, A.B., Alferova, V.V., Gusev, E.I., Nikolaeva, T.Y. (2004). Dialectics and implications of natural neurotropic autoantibodies in neurological disease and rehabilitation. Clinical and Developmental Immunology, 11 (2), 151-156.
Prokhorova, A.V. (2011). The role of neuroimmune dysregulation in the pathogenesis of post-traumatic epilepsy in children. Journal of Theoretical and Clinical Medicine, Tashkent, 5, 64-67, in Russian.
Rakhimbaeva, G.S., Prokhorova, A.V., Tuychibaeva, N.M. (2009). Modern aspects of diagnosis of epilepsy and principles of rational anti-epileptic therapy. Method. Recommend., Tashkent, 44 p., in Russian.
Rashidova, N.S. (2009). Clinical and diagnostic features of different forms of epilepsy and their medicamentous correction. Clinical Medicine of Kazakhstan, Astana, 1, 56-58, in Russian.
Copyright information
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (Creative Commons Attribution License 3.0 - CC BY 3.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
info@cbuni.cz, www.cbuni.cz, ojs.journals.cz
