Liver Mitochondrial Enzyme System In The Dynamics Of Experimental Leukemia

Gulmira Kasymova; Ulugbek Zaribbaev

doi:10.12955/emhpj.v4i0.361

Gulmira Kasymova Research Institute of Hematology and Blood Transfusion, Tashkent
Ulugbek Zaribbaev Research Institute of Hematology and Blood Transfusion, Tashkent

DOI: https://doi.org/10.12955/emhpj.v4i0.361

Keywords: Experimental Leukemia, Liver, Mitochondria, Enzyme System

Abstract

In rats with leukemia activity of liver mitochondrial enzymes are decreased at 6 months. Later, we noted compensatory activation of complexes II and III of the respiratory chain and transition to decompensation stage by final deadline. The activity of complex IV of the respiratory chain remains high. These changes result from increased lipid peroxidation and decreased activity of antioxidant protection enzymes.

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