SYNTHESIS EVALUATION AND QUANTUM MECHANICAL CHARACTERIZATION OF CYCLOHEXYLAMINE CONTAINING DERIVATIVES OF METHYLXANTHINE

  • Maya Georgieva Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia
  • Javor Mitkov Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia
  • Lily Peikova Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia
  • Plamen Peikov Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia
  • Alexander Zlatkov Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia
Keywords: 1 or 8- substituted methylxanthines, structural analysis, spectral analysis.

Abstract

The synthesis of methylxanthine derivatives could provide a sound approach to developing new analogues with similar or novel pharmacological profiles. The synthesis of six new compounds: two derivatives of 8-substituted-1,3,7-trimethylxanthine and four derivatives of 1-propyl-3,7-dimethylxanthine containing a cyclohexyl fragment, are presented. The structures were confirmed by elemental analyses using Furrier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) spectral data. The chemical reactivity of the new molecules was assessed, based on computed values for their electrophilicity index, molecular hardness, and chemical potential. The structures were identified as hard molecules, relatively inert to electrophilic attack, whereas Compound10d was outlined as the most prominent for accepting electrons.

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Published
2016-09-26