EVALUATION OF TITANIUM AQUACOMPLEXGLITSEROSOLVATE AND OXYTOCIN IN THE TREATMENT OF SOFT TISSUE WOUNDS IN EXPERIMENT

Olesya Mokhova

Abstract


In the context of the above properties of titaniumaquacompleхglycerosolvate and oxytocin we have studied their joint application in order to increase the efficiency of treatment of soft tissue wounds. In the investigation performed, 144 experimental animals (white rats) with simulated aseptic wounds were studied. This study will contribute to develop a new treatment for soft tissue wounds, based on the application of aquaglitserosolvatetitanium and oxytocin, examine and assess the effectiveness of aquaglitserosolvatetitanium and oxytocin in the treatment of experimental soft tissue wounds. To assess the process of wound healing in the experiment, methods of clinical, planimetric progressive examinations of wounds, as well as strength characteristics of the scar formed were used. One of the objective measures of wound healing is the study of changes in the area in the healing process. The wound area was calculated by the method of L. N. Popovoy (1942). On the basis of clinical and planimetric methods of investigation, it was found that the decrease in the wound area is significantly faster under the influence of oxytocin and titanium aquacomplexglycerosolvate. 


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Basieva, O. Z. (1999). Pochechnaya gemodinamicheskiye effekty oksitotsina i kaltsiyreguliruyuschih gormony krys so spontannoy gipertenziyey i nesakharnyy diabet nasledstvennykh [Renal hemodynamic effects of oxytocin and calcium regulatory hormones in spontaneously hypertensive rats and hereditary diabetes insipidus]. (Doctoral dissertation). Vladikavkaz, Russia: North - Osetin.med.akadamy.

Bayat, M. (ed.) (2006). Experimental wound healing using microamperage electrical stimulation in rabbits. J. Rehabil. Res. Dev., 43 (2), 219-226, 2006. doi: 10.1682/JRRD.2005.05.0089

Bazhenov, S. M. (ed.) (1997). Osobennosti zazhivleniya gnoynykh ran s pomoshchyu plazmennykh khirurgicheskikh nastroyki: Eksperimental'noye morfologicheskoye issledovaniye [Features of healing of purulent wounds using plasma surgical settings: Experimental morphological study]. Aktualnyye problemy stomatologii [Actual problems of dentistry], 1, pp. 80-84. Smolensk.

Bukharin, O. V., Ivanov, J. B., Kuzmin, M. D. & Mikhailenko, S. V. (Eds.) (1982). Kharakternyye izmeneniya mikroflory u bolnykh s khronicheskim nespetsificheskim uretritom [Characteristic changes in microbiota in patients with chronic non-specific urethritis]. Mikrobiologii , epidemiologii i immunologii [Microbiology, Epidemiology and Immunol.], 1, 48-57.

Bulynin, V. I. (ed.) (1995). Novyy sposob lecheniya ran s ozonom lecheniya ispravleniyu [A new way to treat wounds with ozone remedial treatments]. Byulleten giperbaricheskoy meditsiny i biologii [Bulletin of hyperbaric medicine and biology], 1-2, 29-39.

Chiang, B. (ed.) (2007). Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Am. J. Surg., 193 (2), 213-218,-446. http://dx.doi.org/10.1016/j.amjsurg.2006.08.069, PMid:17236849 PMCid:PMC1850226

Datsenko, B. M. (1985). Teoriya i praktika mestnogo lecheniya ran [Theory and practice of the local treatment of wounds]. Kiev, Ukraine: Health.

Davydov, Y. A. & Larichev, A. B. (1999). Vakuumnoy terapii i protsess zazhivleniya ran [Vacuum therapy and wound healing process]. Moscow, Russia: Medicine. PMCid:PMC3455962

Glukhov, A. A. & Abakumov, V. I. (2008). Regionalnyy gidropressivno- sorbtsiya terapii v kompleksnom lechenii bolnykh s gnoynymi ranami [Regional hydrocompresive sorption therapy in the complex treatment of patients with purulent wounds]. Zhurnal eksperimentalnoy i klinicheskoy khirurgii [Journal of Experimental and Clinical Surgery], 1 (1), 30-36.

Gostishchev, V. K. (1996). Operativnaya gnoynaya khirurgiya [Operational purulent surgery]. Moscow, Russia: Medicine. PMid:9011656

Gostishchev, V. K. (2003). Nekrektomiya: yego vozmozhnosti i yego mesto v sovremennoy khirurgii. 50 lektsiy po khirurgii [Necrosectomy: its possibilities and its place in modern surgery.50 lectures on surgery]. (pp. 344-350). Moscow, Russia: Media Medica.

Hartel, M. (ed.) (2006). Randomized clinical trial of the influence of local water-filtered infrared. An irradiation on wound healing after abdominal surgery. Br. J. Surg., 93 (8), 952-960. http://dx.doi.org/10.1002/bjs.5429, PMid:16845694

Kostyuchenok, B. M., Karlov, V. A. & Gerasimov, M. V. (1984). Vakuumnyye lecheniya gnoynykh ran [Vacuum treatment of purulent wounds]. Sovetskaya meditsina [Soviet medicine], 2, 108-112.

Kurlaev, P. P., Skorobogatykh, Y. I. & Perunova, N. B. (2010). Vliyaniye tsiprofloksatsin, oksitotsin i ikh kombinatsii na obrazovaniye bioplenok uslovno - patogennykh mikroorganizmov [Effect of ciprofloxacin, oxytocin and their combination on the formation of biofilms is conditional - pathogenic microorganisms]. Aktualnyye problemy khirurgii [Actual problems of surgery], 8, 139 – 142. Chelyabinsk.

Kuzin, M. I. &, and B.M. Kostyuchenok, B. M. (1990). Rany i ranevoy infektsii [Wounds and wound infection]. Moscow, Russia: Medicine.

Miroshin, S. M. (1995). Rezultaty klinicheskogo primeneniya ozonirovannoy antiseptikov dlya lecheniya gnoynykh ran. Ozon v biologii i meditsine [Results of clinical application of ozonated antiseptics for the treatment of purulent wounds. Ozone in biology and medicine]. Materials of II All-Russia Scientific-practical conference with international participation held in Nizhny Novgorod in 1995.

Omorov, R. A., Musaev, A. I. & Asylbashev, R. (2003). Lecheniye gnoynykh ran ispolzovaniyem ozonirovannoy resheniya i sorbenta SUMMY -1 [Treatment of purulent wounds using ozonated solutions and sorbent SUMS-1]. Klinicheskaya mikrobiologiya i antimikrobnaya terapiya [Clinical Microbiology and Antimicrobial Therapy], 5 (1), 28, 2003.

Popova, L. N. (1942). Kak izmeryayutsya granitsy vnov obrazuyushchegosya epidermisa pri zazhivlenii ran [As measured by the boundaries of the newly formed epidermis in the healing of wounds]. (Doctoral dissertation). Voronezh, Russia: Voronezh N.N. Burdenko State Medical Academy.

Scardino, M. S. (ed.) (1998). Evaluation of treatment with a pulsed electromagnetic field on wound healing, clinicopathologic variables, and central nervous system activity of dogs. Am. J. Vet. Res.,59 (9), 1177-1181. PMid:9736399

Smagina, T. A. & Beketov, B. N. (2006). Perspektivy meditsinskogo ispolzovaniya titaniumaquacomplexglycerosolvate produktov na yego osnove. [Perspectives medical use titaniumaquacomplexglycerosolvate products based on it]. Byulleten sibirskoy meditsiny [Bulletin of the Siberian medicine], 1, 131-133.

Sychennikov, I. A., Kuzmenko, Y. M. & Ilina, T. M. (1980). Fiziologii i patologii soyedinitelnoy tkani [Physiology and Pathology of Connective Tissue]. Novosibirsk, Russia: Novosibirsk State Medical University.




DOI: http://dx.doi.org/10.12955/cbup.v1.54

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