CERVICAL BRUCELLOSIS, WITH OR WITHOUT BONE INJURY

  • Ergys Ramosaço Faculty of Technical Medical Sciences, University of Medicine, Tirane, Albania
  • Entela Kolovani Infectious Diseases Clinic, University Hospital Center “Mother Teresa”
  • Arben Rroji Imaging Service, University Hospital Center “Mother Teresa”
  • Dhimiter Kraja Infectious Diseases Clinic, University Hospital Center “Mother Teresa”
Keywords: Brucellosis, cervical, diagnose, early, treatment

Abstract

Brucellosis is a zoonotic infectious systemic, endemic in Albania, which is accompanied by multi-organ involvement. A common complication is also the vertebral affection. Manifestation in the lower lumbar spine is frequently seen, while cervical involvement is more rare. Diagnose of vertebral involvement is difficult because of non-specific clinical symptoms. We present two cases of cervical brucellosis, with various cervical injuries. Spondylodiscitis with epidural abscess were the cervical manifestation in the first patient, which is very rare and a serious complication and the second patient had epidural involvement without spondylodiscitis. The Rose Bengal, Wright test, ELISA were positive for both patients. The cervical injury was confirmed with MRI exams. After prolonged combination therapy with cervical immobilization, the follow up evaluation demonstrated resolution of the cervical injury. Because vertebral destruction is in the base of this complication, early diagnosis of vertebral brucellosis is important to prevent serious morbidity, if diagnosis and treatment are delayed. Standard Brucella tube agglutination (Wright) test is the primary test and should be performed as a first step in the differential diagnosis of spondylodiscitis. An MRI is recommended for early diagnosis of spinal involvement. Medically treatment of cervical brucellosis has a good prognosis with early diagnosis.

References

Ariza J., et al (1985). Comparative trial of rifampin–doxcycline versus tetracycline–streptomycin in the therapy of human brucellosis. Antimicrob Agents Chemother, 28 pp. 548–551

al-Shahed, M.S., Sharif, H.S., Haddad, M.C., Aabed, M.Y., Sammak, B.M., Mutairi, M.A. (1994). Imaging features of musculoskeletal brucellosis. Radiographics; 14: 333-348.

Colmenero, J.D., Ruiz-Mesa, J.D., Plata, A, Bermúdez, P., Martín-Rico, P., Queipo-Ortuño, M.I., Reguera, J.M. (2008). Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis. Clinical infectious diseases, 46:426–33.

Colmenero, J.D., Reguera, J.M., Martos, F., Sánchez-De-Mora, D., Delgado, M., Causse, M., Martín-Farfán, A., Juárez, C. (1996). Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine;75:195-211.

Doganay, M., Aygen B. (2003). Human brucellosis: an overview. Int J Infect Dis, 7, pp. 173–182

Alp E., Doganay M. (2008). Current therapeutic strategy in spinal brucellosis. Int J Infect Dis 12(6): 573-577

Eltari E (1981). Bruceloza në Shqipëri. Shtëpia botuese e librit shkollor, 28: 30-39

Erdem, H., Elaldi, N., Batirel, A., Aliyu, S., Sengoz, G., Pehlivanoglu, F., Ramosaco, E., Gulsun, S., Tekin, R., Mete, B et al. (2015). Comparison of Brucellar and Tuberculous Spondylodiscitis Patients: Results of the Multicenter "Backbone-1 Study". Spine J 15 (12), 2509-2517

Ilirian, K., Çabeli, P., Dhaskali, L., Muhedini, P. (2004): Bruceloza në Ripertypës e Tashmja dhe e Ardhmja.

Irmak H, Buzğan T, Sakarya N, Sakarya ME. Spinal brusellozda manyetik rezonans görüntüleme bulguları. Tıp Araştırmaları Derg 2004;2:43-6

Kurtaran, B., Sarpel, T., Tasova, Y., Candevir, A., Saltoglu, N., Inal, A.S., Aksu, H.S.Z. (2008). Brucellar and tuberculous spondylitis in 87 adult patients a descriptive and comparative series. Infect Dis Clin Pract;16:166-73.

Madkour MM : Harrison's Principles of Internal Medicine in Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Fauci AS(eds) : Brucellosis, ed 14. : McGraw-Hill Professional, 2001, Vol 2, pp969-971.

Mariani E, Pulluqi P, Roshi E, Petrela E, Buzali E (2014). Epidemiological and clinical features of brucellosis in hospitalized patients in Albania. Medicus. Vol 19 (3).

Mousa, A.R., Muhtaseb, S.A., Almudallal, D.S., Khodeir, S.M., Marafie, A.A. (1987). Osteoarthicular complications of brucellosis: a study of 169 cases. Rev Infect Dis. 9: 531–543

Mutolo, M.J., Jenny, L.L., Buszek, A.R., Fenton, T.W., Foran, D.R. (2012). Osteological and Molecular Identification of Brucellosis in Ancient Butrint, Albania. American Journal of Physical Anthropology. 147:254–263

Pappas, G., Seitaridis, S., Akritidis, N., Tsianos, E. (2004). Treatment of brucella spondylitis: lessons from an impossible meta-analysis and initial report of efficacy of a fluoroquinolone-containing regimen. Int J Antimicrob Agents. 24(5):502-7.

Pourbagher, A., Pourbagher, M.A., Savas, L., Turunc, T., Demiroglu, Y.Z., Erol, I., Yalcintas, D. (2006). Epidemiologic, clinical, and imaging findings in brucellosis patients with osteoarticular involvement. Am J Roentgenol. 187: 873–880

Resnick D. (1995). Diagnosis of bone and joint disorders. 3rd ed. Philadelphia: Saunders, 4: 2448-2558.

Solera, J., Lozano, E., Martínez-Alfaro, E., Espinosa, A., Castillejos, M.L., Abad, L. (1999). Brucellar spondylitis: review of 35 cases and literature survey. Clin Infect Dis;29:1440-9

Samra, Y., Hertz, M., Shaked, Y., Zwas, S., Altman, G. (1982). Brucellosis of the spine. A report of 3 cases. J Bone Joint Surg 64B : 429-431,

Tekkök, I.H., Berker, M., Ozcan, O.E., Ozgen, T., Akalin, E. (1993). Brucellosis of the spine. Neurosurgery.;33(5): 838-44.

Ulu-Kilic, A., Karakas, A., Erdem, H., Turker, T., Inal, A.S., Ak, O., Turan, H., Kazak, E., Inan, A., Duygu, F et al. (2013). Update on treatment options for spinal brucellosis. Clinical Microbiology and InfectionVolume 20, Issue 2,

Ural, O., Sümer, S., Aktug Demir, N., Dikici, N., Firat, V. (2013). Isolated Cervical Spondylodiscitis Due to Brucellosis: A Case Report.. Turk J Phys Med Rehab 59:256-9

Young, E.J. (2010). Brucella species. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Elsevier Churchill Livingstone;. p. 2921-5.

Zormpala, A., Skopelitis, E., Thanos, L., Artinopoulos, C., Kordossis, T., Sipsas, N.V. (2000). An unusual case of brucellar spondylitis involving both the cervical and lumbar spine. Clin Imaging;24:273-5

Published
2017-09-23